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KMID : 1237720120450020073
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Anatomy & Cell Biology
2012 Volume.45 No. 2 p.73 ~ p.78
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From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers
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Nurwidya Fariz
Takahashi Fumiyuki
Minakata Kunihiko
Murakami Akiko
Takahashi Kazuhisa
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Abstract
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Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is known to be associated with radio/chemo-resistance and metastasis that eventually lead to cancer progression contributing to poor prognosis in cancer patients. Among transcription factors that accumulated under hypoxic conditions, hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that has received the most intense attention in this field of research due to its capacity to modulate several hundred genes. With a clearer understanding of the HIF-1 pathway, efforts are directed at manipulation of this complex genetic process in order to ultimately decrease cellular HIF-1 levels. Some novel agents have been shown to have HIF-1 inhibition activity through a variety of molecular mechanisms and have provided promising results in the preclinical setting
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KEYWORD
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Tumor hypoxia, Cancer progression, Hypoxia-inducible factor-1
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